RELCH

Across TCGA patient cohorts, RELCH mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELCH-associated genes across cancer lineages are PCNA, JNK2, and MSH2. Each is linked with RELCH in more than 1 cancer types. Because this analysis shows association rather than direction, both RELCH-to-partner and partner-to-RELCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RELCH-low versus RELCH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELCH→partner) and Y-score (partner→RELCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.293	+2.321	.002	.035	3	2
UCEC	JNK2 →	+0.216	+1.775	<.001	.007	3	2
UCEC	MSH2 →	-0.269	-2.781	<.001	.003	3	2
UCEC	ATM →	-0.419	-3.571	.005	.002	3	2
COAD	p21 →	+0.218	+2.212	.034	.033	3	1
UCEC	EGFR_pY1068 →	-0.175	-2.000	.034	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PCNA by RELCH expression — SKCM

Explore this box plot interactively →