RELCH

Across TCGA cell cohorts, RELCH mutation is significantly associated with the RNA expression of many other genes, with 825 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RELCH-associated genes across cancer lineages are BPIFB6, LINGO4, and SCGB1D1. Each is linked with RELCH in more than 1 cancer types. Because this analysis shows association rather than direction, both RELCH-to-partner and partner-to-RELCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by RELCH-low versus RELCH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELCH→partner) and Y-score (partner→RELCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	2
BLOOD_Leukemia	LINGO4 →	+0.198	+4.481	<.001	<.001	3	2
LUNG_SCLC	SCGB1D1 →	+2.546	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF14 →	+0.281	+4.523	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 825 associations by consensus.

BPIFB6 by RELCH expression — BLOOD_Leukemia

Explore this box plot interactively →