RELB

Across TCGA patient cohorts, RELB mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELB-associated genes across cancer lineages are EGFR_pY1068, Ku80, and JNK2. Each is linked with RELB in more than 1 cancer types. Because this analysis shows association rather than direction, both RELB-to-partner and partner-to-RELB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RELB-low versus RELB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELB→partner) and Y-score (partner→RELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.241	-3.584	.047	.002	3	2
UCEC	Ku80 →	+0.273	+3.179	.016	.010	3	2
UCEC	JNK2 →	+0.251	+2.459	.008	.020	2	2
UCEC	Bax →	+0.300	+2.459	.009	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.907	+3.189	.001	.010	3	1
UCEC	INPP4B →	-0.321	-3.000	.040	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by RELB expression — UCEC

Explore this box plot interactively →