RELB

Across TCGA cell cohorts, RELB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,884 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RELB-associated GO terms across cancer lineages are Canonical NF-kappaB signal transduction, Non-canonical NF-kappaB signal transduction, and Response to manganese ion. Each is linked with RELB in more than 18 cancer types. Because this analysis shows association rather than direction, both RELB-to-partner and partner-to-RELB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Canonical NF-kappaB signal transduction grouped by RELB-low versus RELB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RELB→partner) and Y-score (partner→RELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Canonical NF-kappaB signal transduction →	+0.111	+1.361	<.001	<.001	3	19
PANCREAS	Non-canonical NF-kappaB signal transduction →	+0.108	+1.108	<.001	<.001	3	17
BREAST	Response to manganese ion →	+0.158	+1.529	<.001	<.001	3	14
BREAST	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.173	+1.302	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.071	+1.019	.002	<.001	3	13
LUNG_NSCLC_LUSC	Leukemia inhibitory factor signaling pathway →	+0.300	+1.972	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,884 associations by consensus.

Canonical NF-kappaB signal transduction by RELB expression — OESOPHAGUS

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