RELB

Across TCGA cell cohorts, RELB mutation is significantly associated with the RNA expression of many other genes, with 510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RELB-associated genes across cancer lineages are SFTPC, PRAMEF15, and ALDH6A1. Each is linked with RELB in more than 1 cancer types. Because this analysis shows association rather than direction, both RELB-to-partner and partner-to-RELB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFTPC grouped by RELB-low versus RELB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELB→partner) and Y-score (partner→RELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SFTPC →	+0.072	+2.977	<.001	.004	3	2
LUNG_SCLC	PRAMEF15 →	+0.382	+3.817	<.001	.004	3	2
LARGE_INTESTINE	ALDH6A1 →	+1.089	+3.234	<.001	.004	3	2
LARGE_INTESTINE	SMIM33 →	+0.722	+3.355	<.001	.007	3	2
SKIN	PRAMEF6 →	+0.128	+3.920	<.001	.005	3	2
BLOOD_Lymphoma	TAS2R38 →	+0.177	+4.350	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 510 associations by consensus.

SFTPC by RELB expression — BLOOD_Leukemia

Explore this box plot interactively →