RELA

Across TCGA pan-cancer cohorts, RELA Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RELA data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RELA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RELA expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

LUAD, ESCA, and PRAD are the cancer types where RELA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.299	0.815	<.001	24	view →
ESCA	OS	Median	All	0.198	0.872	.003	18	view →
PRAD	DFS	Median	All	0.594	0.886	.043	6	view →
STAD	OS	Median	III,IV	1.000	0.367	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RELA–LUAD (OS)

Open the LUAD breakdown →