RELA

Across TCGA pan-cancer cohorts, RELA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RELA data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RELA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RELA expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, PDAC, and GBM are the cancer types where RELA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.895	0.596	.019	13	view →
PDAC	OS	Median	III,IV	0.321	0.557	.018	11	view →
GBM	DFS	Median	All	0.615	0.818	.010	7	view →
LSCC	DFS	Tertile	III,IV	0.677	1.000	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RELA–HNSC (DFS)

Open the HNSC breakdown →