RELA

Across TCGA patient cohorts, RELA mutation is significantly associated with the RNA expression of many other genes, with 2,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELA-associated genes across cancer lineages are MIR3912, TRAJ12, and OR11H12. Each is linked with RELA in more than 1 cancer types. Because this analysis shows association rather than direction, both RELA-to-partner and partner-to-RELA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3912 grouped by RELA-low versus RELA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELA→partner) and Y-score (partner→RELA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3912 →	+0.286	+3.476	<.001	.005	3	2
CESC	TRAJ12 →	+0.721	+4.608	<.001	.001	3	2
BLCA	OR11H12 →	+0.031	+4.314	<.001	.009	3	2
SARC	RPL23AP56 →	+0.220	+5.005	<.001	.009	3	2
SARC	MIR3196 →	+0.581	+5.005	.008	.009	3	2
SARC	RPSAP57 →	+0.064	+5.111	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,095 associations by consensus.

MIR3912 by RELA expression — COAD

Explore this box plot interactively →