REL

Across TCGA pan-cancer cohorts, REL mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated REL data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher REL mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated REL expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where REL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.848	.003	34	view →
CCRCC	OS	Tertile	III,IV	0.434	0.870	.003	25	view →
PDAC	OS	Median	All	0.688	0.953	.002	25	view →
HNSC	DFS	Quartile	III,IV	0.547	0.847	.017	13	view →
GBM	DFS	Quartile	All	0.253	0.523	.010	8	view →
COAD	DFS	Quartile	III,IV	0.796	1.000	.031	6	view →
LUAD	OS	Median	All	0.689	0.903	.039	2	view →
LSCC	OS	Median	II,III,IV	1.000	0.905	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

REL–UCEC (OS)

Open the UCEC breakdown →