REL

Across TCGA patient cohorts, REL mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REL-associated genes across cancer lineages are MSH2, mTOR, and PCNA. Each is linked with REL in more than 1 cancer types. Because this analysis shows association rather than direction, both REL-to-partner and partner-to-REL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by REL-low versus REL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REL→partner) and Y-score (partner→REL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.199	-1.973	.014	.029	3	2
UCEC	mTOR →	-0.185	-1.662	.001	.011	3	2
UCEC	PCNA →	+0.271	+2.906	<.001	.001	3	2
UCEC	Src_pY527 →	-0.305	-1.874	.045	.049	3	2
UCEC	14-3-3_beta →	-0.077	-1.847	.030	.049	3	1
UCEC	eEF2 →	+0.254	+1.362	.044	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MSH2 by REL expression — UCEC

Explore this box plot interactively →