REL

Across TCGA cell cohorts, REL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,348 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible REL-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Positive regulation of mRNA metabolic process, and Endosomal transport. Each is linked with REL in more than 15 cancer types. Because this analysis shows association rather than direction, both REL-to-partner and partner-to-REL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by REL-low versus REL-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REL→partner) and Y-score (partner→REL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome condensation →	+0.211	+1.245	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Positive regulation of mRNA metabolic process →	+0.090	+1.005	<.001	.003	3	16
OESOPHAGUS	Endosomal transport →	+0.097	+1.236	<.001	<.001	3	15
OESOPHAGUS	Regulation of mRNA stability →	+0.081	+1.178	<.001	<.001	3	15
BONE	Nucleic acid transport →	+0.123	+0.963	.001	<.001	3	15
BONE	RNA transport →	+0.123	+0.963	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,348 associations by consensus.

Negative regulation of chromosome condensation by REL expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →