REL

Across TCGA cell cohorts, REL mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible REL-associated genes across cancer lineages are Nutlin-3a (-), KRAS (G12C) Inhibitor-12, and SU11274. Each is linked with REL in more than 1 cancer types. Because this analysis shows association rather than direction, both REL-to-partner and partner-to-REL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by REL-low versus REL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REL→partner) and Y-score (partner→REL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+0.754	+2.646	.040	.047	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.505	+2.646	.043	.047	3	1
LARGE_INTESTINE	SU11274 →	+0.601	+2.652	.003	.045	3	1
LARGE_INTESTINE	GSK690693 →	+0.712	+2.652	.004	.045	3	1
LARGE_INTESTINE	L-Oxonoreleagnine →	+0.390	+2.777	.007	.038	2	1
LARGE_INTESTINE	Sinularin →	+0.397	+2.777	.010	.038	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Nutlin-3a (-) by REL expression — LARGE_INTESTINE

Explore this box plot interactively →