REG3A

Across TCGA pan-cancer cohorts, REG3A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of REG3A’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where REG3A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types REG3A is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

PDAC, COAD, and CCRCC are the cancer types where REG3A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REG3A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.890	<.001	8	view →
COAD	All	II,III,IV	−0.505	.010	5	view →
CCRCC	All	All	−0.624	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

REG3A–PDAC

Open the PDAC breakdown →