REG3A

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, REG3A protein abundance is significantly associated with the RNA expression of many other genes, with 2,053 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible REG3A-associated genes across cancer lineages are AXIN1, CEACAM5, and REG1A. Each is linked with REG3A in more than 1 cancer types. Because this analysis shows association rather than direction, both REG3A-to-partner and partner-to-REG3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, REG3A versus AXIN1 in COAD, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG3A→partner) and Y-score (partner→REG3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADAXIN1 →-0.543-1.117.001<.00132
LUADCEACAM5 →-6.222-3.460.002.00732
COADREG1A →+4.714+1.568<.001<.00132
PDACCRP →+1.957+0.916<.001<.00132
PDACREG3G →+3.487+1.260<.001<.00132
PDACPTF1A →+1.132+1.214<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,053 associations by consensus.

REG3A vs AXIN1 — COAD

Per-sample scatter of REG3A vs AXIN1 in COAD (Pearson r = -0.33).

Explore this scatter interactively →

Exploration