REG3A

Across TCGA patient cohorts, REG3A mutation is significantly associated with the RNA expression of many other genes, with 4,396 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REG3A-associated genes across cancer lineages are CAAP1, CASTOR2, and PCGF6. Each is linked with REG3A in more than 3 cancer types. Because this analysis shows association rather than direction, both REG3A-to-partner and partner-to-REG3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAAP1 grouped by REG3A-low versus REG3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG3A→partner) and Y-score (partner→REG3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CAAP1 →	+0.556	+1.928	.003	.009	3	4
UCEC	CASTOR2 →	+0.822	+2.447	<.001	.001	3	4
SKCM	PCGF6 →	+0.536	+2.227	.001	.001	3	4
UCEC	KIAA1841 →	+0.505	+2.532	.001	.009	3	4
UCEC	FAM136A →	+0.596	+3.098	<.001	<.001	3	4
SKCM	RBM15B →	+0.332	+2.729	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,396 associations by consensus.

CAAP1 by REG3A expression — UCEC

Explore this box plot interactively →