REG3A

Across TCGA cell cohorts, REG3A RNA expression is significantly associated with the go_rna of many other GO terms, with 185 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible REG3A-associated GO terms across cancer lineages are Regulation of cardiac muscle cell membrane repolarization, Regulation of pentose-phosphate shunt, and Negative regulation of DNA binding. Each is linked with REG3A in more than 2 cancer types. Because this analysis shows association rather than direction, both REG3A-to-partner and partner-to-REG3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cardiac muscle cell membrane repolarization grouped by REG3A-low versus REG3A-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REG3A→partner) and Y-score (partner→REG3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of cardiac muscle cell membrane repolarization →	+0.162	+0.503	.003	.009	3	3
OVARY	Regulation of pentose-phosphate shunt →	-0.092	-0.021	.004	.009	3	3
BREAST	Negative regulation of DNA binding →	+0.138	+0.012	<.001	.005	3	3
SOFT_TISSUE	Disruption of cellular anatomical structure in another organism →	+1.047	+0.638	<.001	.008	3	2
SOFT_TISSUE	Oocyte growth →	+0.200	+0.661	<.001	.006	3	2
SOFT_TISSUE	Formation of cytoplasmic translation initiation complex →	+0.083	+0.340	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 185 associations by consensus.

Regulation of cardiac muscle cell membrane repolarization by REG3A expression — STOMACH

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