REG3A

Across TCGA cell cohorts, REG3A mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible REG3A-associated genes across cancer lineages are OR10G2, ADAM2, and CNTN6. Each is linked with REG3A in more than 1 cancer types. Because this analysis shows association rather than direction, both REG3A-to-partner and partner-to-REG3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G2 grouped by REG3A-low versus REG3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG3A→partner) and Y-score (partner→REG3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10G2 →	+0.043	+4.977	.008	.007	3	1
LUNG_NSCLC_LUAD	ADAM2 →	+0.055	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	CNTN6 →	+0.645	+4.054	<.001	.004	3	1
LUNG_NSCLC_LUAD	RTP1 →	+0.064	+3.866	<.001	.006	3	1
LUNG_NSCLC_LUAD	LIPN →	+0.025	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR4D10 →	+0.031	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR10G2 by REG3A expression — LARGE_INTESTINE

Explore this box plot interactively →