REG3A

Across TCGA cell cohorts, REG3A mutation is significantly associated with the mutation status of many other genes, with 952 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible REG3A-associated genes across cancer lineages are ZNF224, NUP210, and ARHGAP24. Each is linked with REG3A in more than 2 cancer types. Because this analysis shows association rather than direction, both REG3A-to-partner and partner-to-REG3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF224 grouped by REG3A-low versus REG3A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG3A→partner) and Y-score (partner→REG3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF224 →	+4.584	+4.584	.007	.007	1	3
CNS	NUP210 →	+4.044	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	ARHGAP24 →	+3.000	+3.662	.007	.007	1	3
SKIN	CCNB3 →	+4.824	+5.392	.004	.004	1	3
BLOOD_Lymphoma	SCN3A →	+2.710	+4.203	.008	.008	1	3
BLOOD_Lymphoma	CAMTA1 →	+2.847	+4.327	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 952 associations by consensus.

ZNF224 by REG3A expression — BLOOD_Lymphoma

Explore this box plot interactively →