REG1A

Across TCGA pan-cancer cohorts, REG1A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated REG1A data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher REG1A Mutation is associated with better overall survival. In most high-consensus cancer types, elevated REG1A expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

BLCA, SKCM, and SCLC are the cancer types where REG1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	IV	1.000	0.246	.013	12	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	7	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
PRAD	DFS	Median	All	0.085	0.774	.007	6	view →
LIHC	DFS	Median	III,IV	0.116	0.363	.038	6	view →
LGG	OS	Median	All	0.589	0.908	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

REG1A–BLCA (OS)

Open the BLCA breakdown →