REG1A

Across TCGA patient cohorts, REG1A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible REG1A-associated genes across cancer lineages are FoxM1, 4E-BP1_pS65, and Cyclin-B1. Each is linked with REG1A in more than 2 cancer types. Because this analysis shows association rather than direction, both REG1A-to-partner and partner-to-REG1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by REG1A-low versus REG1A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG1A→partner) and Y-score (partner→REG1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.213	+3.188	.038	.009	3	3
LUSC	4E-BP1_pS65 →	+0.276	+3.598	<.001	.001	3	3
LUAD	Cyclin-B1 →	+0.488	+3.321	.013	.009	3	3
UCEC	ATM →	-0.747	-3.169	.002	.020	3	3
LUSC	FOXO3a →	-0.086	-3.000	.020	.033	3	2
LUSC	PREX1 →	-0.149	-2.303	.034	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

FoxM1 by REG1A expression — LUSC

Explore this box plot interactively →