REG1A

Across TCGA cell cohorts, REG1A RNA expression is significantly associated with the go_rna of many other GO terms, with 609 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible REG1A-associated GO terms across cancer lineages are Positive regulation of cell junction assembly, Positive regulation of gap junction assembly, and Regulation of protein localization to endoplasmic reticulum. Each is linked with REG1A in more than 5 cancer types. Because this analysis shows association rather than direction, both REG1A-to-partner and partner-to-REG1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell junction assembly grouped by REG1A-low versus REG1A-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REG1A→partner) and Y-score (partner→REG1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of cell junction assembly →	-0.051	-0.066	.003	.006	3	6
STOMACH	Positive regulation of gap junction assembly →	-1.039	-1.984	<.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to endoplasmic reticulum →	+0.084	+0.596	<.001	<.001	3	4
CNS	Subtelomeric heterochromatin formation →	+0.057	+0.070	.001	.003	2	5
STOMACH	Regulation of gap junction assembly →	-1.423	-2.695	<.001	.007	3	3
STOMACH	Cellular response to nitrogen levels →	-0.130	-2.554	<.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 609 associations by consensus.

Positive regulation of cell junction assembly by REG1A expression — CNS

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