REG1A

Across TCGA cell cohorts, REG1A mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible REG1A-associated genes across cancer lineages are OR13C3, CT45A7, and LHCGR. Each is linked with REG1A in more than 1 cancer types. Because this analysis shows association rather than direction, both REG1A-to-partner and partner-to-REG1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C3 grouped by REG1A-low versus REG1A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REG1A→partner) and Y-score (partner→REG1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR13C3 →	+0.010	+2.887	<.001	.009	3	2
LUNG_NSCLC_LUAD	CT45A7 →	+0.032	+3.684	<.001	<.001	3	2
BLOOD_Leukemia	LHCGR →	+0.268	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR4D9 →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OR2T10 →	+0.602	+4.409	<.001	.005	3	1
BLOOD_Leukemia	KRTAP19-5 →	+0.686	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR13C3 by REG1A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →