REEP6

Across TCGA pan-cancer cohorts, REEP6 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated REEP6 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher REEP6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated REEP6 expression acts as an unfavorable survival marker.

ACC, HNSC, and TGCT are the cancer types where REEP6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
HNSC	OS	Median	All	0.176	0.685	.024	30	view →
TGCT	DFS	Median	All	0.146	0.801	.020	6	view →
SKCM	OS	Median	III,IV	0.216	0.697	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

REEP6–ACC (DFS)

Open the ACC breakdown →