REEP6

Across TCGA pan-cancer cohorts, REEP6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated REEP6 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher REEP6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated REEP6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where REEP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.277	0.886	.001	17	view →
HNSC	DFS	Tertile	III,IV	0.382	1.000	.014	9	view →
CCRCC	DFS	Tertile	II,III,IV	0.720	0.356	.013	3	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.654	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

REEP6–LUAD (DFS)

Open the LUAD breakdown →