REEP5

Across TCGA pan-cancer cohorts, REEP5 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated REEP5 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher REEP5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated REEP5 expression acts as an unfavorable survival marker.

THYM, OV, and BLCA are the cancer types where REEP5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
OV	DFS	Median	II,III,IV	0.193	0.541	.013	18	view →
BLCA	OS	Median	All	0.090	0.688	<.001	18	view →
HNSC	OS	Median	All	0.099	0.768	<.001	12	view →
SKCM	OS	Median	All	0.245	0.781	.008	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

REEP5–THYM (OS)

Open the THYM breakdown →