REEP5

Across TCGA pan-cancer cohorts, REEP5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of REEP5’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where REEP5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types REEP5 is over-expressed in tumor, although a few such as LSCC and COAD show the opposite, repressed pattern.

LSCC, COAD, and PDAC are the cancer types where REEP5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REEP5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.345	<.001	8	view →
COAD	All	All	−0.093	.001	5	view →
PDAC	All	All	−0.369	.004	4	view →
CCRCC	Male	All	−0.224	<.001	3	view →
LUAD	All	All	−0.084	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

REEP5–LSCC

Open the LSCC breakdown →