REEP5

Across TCGA patient cohorts, REEP5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REEP5-associated genes across cancer lineages are 14-3-3_beta, GSK3-a-b, and JNK2. Each is linked with REEP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both REEP5-to-partner and partner-to-REEP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by REEP5-low versus REEP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP5→partner) and Y-score (partner→REEP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.111	-2.973	.018	.035	3	1
UCEC	GSK3-a-b →	+0.128	+3.000	.042	.036	3	1
UCEC	JNK2 →	+0.355	+3.026	<.001	.018	3	1
UCEC	Ku80 →	+0.341	+2.331	.001	.019	3	1
UCEC	p27_pT157 →	-0.059	-2.584	.028	.011	3	1
UCEC	PDCD4 →	-0.610	-3.160	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by REEP5 expression — UCEC

Explore this box plot interactively →