REEP5

Across TCGA cell cohorts, REEP5 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,827 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible REEP5-associated GO terms across cancer lineages are Adenylate cyclase-activating G protein-coupled receptor signaling pathway, Establishment or maintenance of cell polarity regulating cell shape, and Positive regulation of potassium ion transport. Each is linked with REEP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both REEP5-to-partner and partner-to-REEP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-activating G protein-coupled receptor signaling pathway grouped by REEP5-low versus REEP5-high in PANCREAS.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REEP5→partner) and Y-score (partner→REEP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Adenylate cyclase-activating G protein-coupled receptor signaling pathway →	-0.104	-1.060	<.001	.001	3	2
PANCREAS	Establishment or maintenance of cell polarity regulating cell shape →	-0.183	-1.060	.002	.001	3	2
BLOOD_Lymphoma	Positive regulation of potassium ion transport →	+0.203	+1.277	.002	.006	3	2
PANCREAS	Negative regulation of lipid storage →	+0.282	+1.015	.003	.008	3	2
PANCREAS	Regulation of amino acid import across plasma membrane →	+0.266	+1.060	.009	.001	3	2
PANCREAS	Regulation of phenotypic switching →	-0.275	-1.060	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,827 associations by consensus.

Adenylate cyclase-activating G protein-coupled receptor signaling pathway by REEP5 expression — PANCREAS

Explore this box plot interactively →