REEP1

Across TCGA pan-cancer cohorts, REEP1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated REEP1 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher REEP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated REEP1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, KIRC, and BLCA are the cancer types where REEP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.416	0.842	<.001	145	view →
KIRC	OS	Tertile	All	0.757	0.584	<.001	87	view →
BLCA	DFS	Tertile	II,III,IV	0.459	0.619	.001	74	view →
UCS	DFS	Quartile	III,IV	0.657	0.162	.004	36	view →
LGG	DFS	Quartile	All	0.566	0.265	<.001	23	view →
ACC	DFS	Tertile	All	0.527	0.799	.013	19	view →
MESO	OS	Quartile	All	0.428	0.235	.024	18	view →
CESC	OS	Tertile	All	0.898	0.749	.002	18	view →
STAD	OS	Quartile	All	0.566	0.810	.010	15	view →
GBM	DFS	Tertile	All	0.380	0.183	.010	12	view →
LUSC	OS	Quartile	III,IV	0.244	0.574	.010	12	view →
CHOL	DFS	Tertile	All	0.674	0.203	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

REEP1–UVM (OS)

Open the UVM breakdown →