REELD1

Across TCGA patient cohorts, REELD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,130 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible REELD1-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of RNA splicing, and Protein localization to vacuole. Each is linked with REELD1 in more than 27 cancer types. Because this analysis shows association rather than direction, both REELD1-to-partner and partner-to-REELD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by REELD1-low versus REELD1-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REELD1→partner) and Y-score (partner→REELD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Positive regulation of double-strand break repair →	+0.074	+0.997	.009	<.001	1	28
ESCA	Regulation of RNA splicing →	+0.087	+0.461	<.001	<.001	3	26
ESCA	Protein localization to vacuole →	+0.084	+0.605	<.001	<.001	3	26
DLBC	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.112	+0.967	<.001	<.001	2	26
DLBC	Obsolete regulation of dosage compensation by inactivation of X chromosome →	+0.100	+0.807	.002	.001	1	27
DLBC	Glycerophospholipid metabolic process →	+0.062	+1.024	.009	<.001	1	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,130 associations by consensus.

Positive regulation of double-strand break repair by REELD1 expression — DLBC

Explore this box plot interactively →