RECQL5

Across TCGA pan-cancer cohorts, RECQL5 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated RECQL5 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher RECQL5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RECQL5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCS, ESCA, and UCEC are the cancer types where RECQL5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.068	0.524	<.001	48	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	30	view →
UCEC	DFS	Median	II,III,IV	1.000	0.302	.004	26	view →
OV	DFS	Median	II,III,IV	0.140	0.541	.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	All	0.350	0.626	.004	13	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
HNSC	OS	Median	All	0.156	0.686	.006	8	view →
COAD	OS	Median	III,IV	0.444	0.797	.015	7	view →
KIRC	OS	Median	All	0.591	0.874	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RECQL5–UCS (DFS)

Open the UCS breakdown →