RECQL5

Across TCGA pan-cancer cohorts, RECQL5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RECQL5 data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RECQL5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RECQL5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where RECQL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.924	0.682	.007	7	view →
CCRCC	DFS	Quartile	All	0.409	0.952	.020	6	view →
GBM	DFS	Tertile	All	0.656	0.836	.006	6	view →
PDAC	OS	Median	All	0.786	0.905	.017	4	view →
LUAD	OS	Median	III,IV	0.808	0.411	.045	2	view →
HNSC	DFS	Quartile	III,IV	0.453	0.773	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RECQL5–LSCC (OS)

Open the LSCC breakdown →