RECQL5

Across TCGA patient cohorts, RECQL5 mutation is significantly associated with the RNA expression of many other genes, with 3,481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RECQL5-associated genes across cancer lineages are SNRPD1, EIF5A, and SNORD115-45. Each is linked with RECQL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RECQL5-to-partner and partner-to-RECQL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD1 grouped by RECQL5-low versus RECQL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL5→partner) and Y-score (partner→RECQL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPD1 →	+0.346	+1.747	.003	<.001	3	3
UCEC	EIF5A →	+0.259	+1.536	.007	.002	3	3
CESC	SNORD115-45 →	+0.287	+4.757	<.001	.004	3	2
COAD	RNFT2 →	+0.459	+3.361	.004	.004	3	2
COAD	C6orf52 →	+1.104	+3.459	<.001	.005	3	2
COAD	NFASC →	-0.540	-3.446	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,481 associations by consensus.

SNRPD1 by RECQL5 expression — UCEC

Explore this box plot interactively →