RECQL5

Across TCGA patient cohorts, RECQL5 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RECQL5-associated genes across cancer lineages are TFRC, MEK1, and Caspase-8. Each is linked with RECQL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RECQL5-to-partner and partner-to-RECQL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by RECQL5-low versus RECQL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL5→partner) and Y-score (partner→RECQL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.453	+2.807	.005	.002	3	3
UCEC	MEK1 →	+0.424	+3.906	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.305	-2.857	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.372	+3.906	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.699	+1.893	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.096	-2.295	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

TFRC by RECQL5 expression — UCEC

Explore this box plot interactively →