RECQL5

Across TCGA cell cohorts, RECQL5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,540 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RECQL5-associated GO terms across cancer lineages are Negative regulation of transcription elongation by RNA polymerase II, Cilium or flagellum-dependent cell motility, and Macroautophagy. Each is linked with RECQL5 in more than 16 cancer types. Because this analysis shows association rather than direction, both RECQL5-to-partner and partner-to-RECQL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription elongation by RNA polymerase II grouped by RECQL5-low versus RECQL5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL5→partner) and Y-score (partner→RECQL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription elongation by RNA polymerase II →	+0.134	+1.082	<.001	.001	3	17
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.139	-1.306	<.001	<.001	3	15
KIDNEY	Macroautophagy →	+0.057	+0.822	.008	.008	3	15
OESOPHAGUS	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.118	+0.799	.001	.007	3	15
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.156	+0.578	<.001	.001	3	15
OESOPHAGUS	Cilium-dependent cell motility →	-0.139	-1.306	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,540 associations by consensus.

Negative regulation of transcription elongation by RNA polymerase II by RECQL5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →