RECQL4

Across TCGA patient cohorts, RECQL4 mutation is significantly associated with the RNA expression of many other genes, with 3,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RECQL4-associated genes across cancer lineages are MND1, RNU7-81P, and CCDC43. Each is linked with RECQL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both RECQL4-to-partner and partner-to-RECQL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MND1 grouped by RECQL4-low versus RECQL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL4→partner) and Y-score (partner→RECQL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MND1 →	+0.556	+2.860	.003	.001	3	4
BLCA	RNU7-81P →	+0.335	+4.233	<.001	.006	3	3
UCEC	CCDC43 →	+0.445	+2.523	<.001	<.001	3	3
UCEC	LYSMD4 →	+0.313	+2.222	<.001	<.001	3	3
UCEC	YRDC →	+0.390	+2.332	.001	.003	3	3
UCEC	SNX2 →	+0.379	+2.397	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,189 associations by consensus.

MND1 by RECQL4 expression — UCEC

Explore this box plot interactively →