RECQL4

Across TCGA patient cohorts, RECQL4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RECQL4-associated genes across cancer lineages are eEF2, eIF4E, and GATA6. Each is linked with RECQL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RECQL4-to-partner and partner-to-RECQL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RECQL4-low versus RECQL4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL4→partner) and Y-score (partner→RECQL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	eEF2 →	+0.348	+2.824	.011	.036	2	3
UCEC	eIF4E →	+0.143	+1.392	.039	.019	3	2
UCEC	GATA6 →	-0.142	-1.584	.005	.034	3	2
UCEC	Lck →	+0.206	+1.392	.001	.019	3	2
UCEC	MSH6 →	-0.330	-1.906	.002	.014	3	2
UCEC	ATM →	-0.459	-1.938	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by RECQL4 expression — BLCA

Explore this box plot interactively →