RECQL4

Across TCGA cell cohorts, RECQL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,413 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RECQL4-associated GO terms across cancer lineages are Nuclear DNA replication, Positive regulation of DNA-directed DNA polymerase activity, and Cell cycle DNA replication. Each is linked with RECQL4 in more than 19 cancer types. Because this analysis shows association rather than direction, both RECQL4-to-partner and partner-to-RECQL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear DNA replication grouped by RECQL4-low versus RECQL4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RECQL4→partner) and Y-score (partner→RECQL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nuclear DNA replication →	+0.216	+2.267	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of DNA-directed DNA polymerase activity →	+0.255	+1.780	<.001	<.001	3	19
BONE	Cell cycle DNA replication →	+0.218	+2.201	<.001	<.001	3	19
OESOPHAGUS	Regulation of DNA-templated DNA replication →	+0.121	+1.742	.003	<.001	3	19
OESOPHAGUS	Meiotic chromosome condensation →	+0.180	+1.259	.001	.003	3	19
OESOPHAGUS	Resolution of mitotic recombination intermediates →	+0.191	+1.364	.003	.002	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,413 associations by consensus.

Nuclear DNA replication by RECQL4 expression — BONE

Explore this box plot interactively →