RECQL

Across TCGA pan-cancer cohorts, RECQL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RECQL data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RECQL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RECQL expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where RECQL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.458	0.798	.002	98	view →
UCEC	OS	Tertile	All	0.885	1.000	.018	16	view →
LUAD	OS	Quartile	All	0.717	0.953	.003	10	view →
PDAC	OS	Tertile	IV	0.973	0.472	.024	6	view →
CCRCC	OS	Median	All	0.730	1.000	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RECQL–HNSC (DFS)

Open the HNSC breakdown →