Across TCGA patient cohorts, REC114 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REC114-associated genes across cancer lineages are A-Raf_pS299, GATA6, and JNK_pT183_Y185. Each is linked with REC114 in more than 1 cancer types. Because this analysis shows association rather than direction, both REC114-to-partner and partner-to-REC114 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REC114→partner) and Y-score (partner→REC114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.221	-3.000	.001	.037	3	1
UCEC	GATA6 →	-0.226	-2.992	.011	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-2.986	.032	.037	3	1
UCEC	Ku80 →	+0.303	+3.013	.026	.019	3	1
UCEC	Myosin-IIa →	+0.271	+3.007	.011	.019	3	1
UCEC	p27_pT157 →	-0.085	-3.000	.010	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

REC114 survival (RNA) · tumor vs normal (RNA) · all REC114 data types