RDH8

Across TCGA patient cohorts, RDH8 mutation is significantly associated with the RNA expression of many other genes, with 362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH8-associated genes across cancer lineages are LINC01201, PRY, and MIR670. Each is linked with RDH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both RDH8-to-partner and partner-to-RDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01201 grouped by RDH8-low versus RDH8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH8→partner) and Y-score (partner→RDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01201 →	+0.185	+5.014	<.001	.002	3	3
SKCM	PRY →	+0.163	+1.867	<.001	.008	3	2
LUSC	MIR670 →	+0.243	+4.578	<.001	.005	3	2
LUSC	OC90 →	+0.068	+4.191	<.001	.009	3	2
UCEC	SLC25A39 →	+0.421	+2.743	.004	.003	3	2
SKCM	LDHA →	+0.577	+2.813	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 362 associations by consensus.

LINC01201 by RDH8 expression — LUAD

Explore this box plot interactively →