RDH8

Across TCGA patient cohorts, RDH8 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RDH8-associated genes across cancer lineages are TFRC, YB-1, and eEF2K. Each is linked with RDH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both RDH8-to-partner and partner-to-RDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by RDH8-low versus RDH8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH8→partner) and Y-score (partner→RDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.726	+3.169	.004	.018	3	1
SKCM	YB-1 →	+0.200	+3.012	.035	.018	3	1
SKCM	eEF2K →	+0.359	+2.182	.027	.033	3	1
UCEC	Claudin-7 →	+0.544	+3.459	.032	.005	1	3
SKCM	Cyclin-B1 →	+0.511	+3.334	.006	.005	2	1
SKCM	ACC1 →	+0.295	+2.584	.039	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TFRC by RDH8 expression — SKCM

Explore this box plot interactively →