RDH8

Across TCGA cell cohorts, RDH8 RNA expression is significantly associated with the go_rna of many other GO terms, with 293 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RDH8-associated GO terms across cancer lineages are Positive regulation of ion transmembrane transporter activity, Response to genistein, and Negative regulation of photoreceptor cell differentiation. Each is linked with RDH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both RDH8-to-partner and partner-to-RDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ion transmembrane transporter activity grouped by RDH8-low versus RDH8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH8→partner) and Y-score (partner→RDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of ion transmembrane transporter activity →	-0.078	-0.057	<.001	.003	3	3
CNS	Response to genistein →	-0.757	-0.082	<.001	.008	3	2
CNS	Negative regulation of photoreceptor cell differentiation →	-0.677	-0.167	<.001	.008	3	2
SKIN	Detoxification of copper ion →	-0.213	-0.992	<.001	.003	3	2
SKIN	Creatine transmembrane transport →	+0.325	+0.602	.001	.001	3	2
SKIN	Fatty-acyl-CoA transport →	+0.143	+0.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 293 associations by consensus.

Positive regulation of ion transmembrane transporter activity by RDH8 expression — UPPER_AERODIGESTIVE_TRACT

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