RDH8

Across TCGA cell cohorts, RDH8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RDH8-associated genes across cancer lineages are HSFY1, IQCF6, and AMELY. Each is linked with RDH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH8-to-partner and partner-to-RDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY1 grouped by RDH8-low versus RDH8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH8→partner) and Y-score (partner→RDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSFY1 →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	IQCF6 →	+0.349	+4.467	<.001	.004	3	1
LARGE_INTESTINE	AMELY →	+0.045	+5.022	<.001	.002	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.046	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

HSFY1 by RDH8 expression — LARGE_INTESTINE

Explore this box plot interactively →