RDH5

Across TCGA patient cohorts, RDH5 mutation is significantly associated with the RNA expression of many other genes, with 762 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH5-associated genes across cancer lineages are SNORD126, RNU1-1, and RNU6-1233P. Each is linked with RDH5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RDH5-to-partner and partner-to-RDH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD126 grouped by RDH5-low versus RDH5-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH5→partner) and Y-score (partner→RDH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	SNORD126 →	+0.324	+3.715	.005	.008	3	3
COAD	RNU1-1 →	+0.634	+5.602	<.001	.004	3	2
KIRP	RNU6-1233P →	+0.203	+4.518	.001	.006	3	2
KIRP	MIR3713 →	+0.476	+4.716	<.001	.005	3	1
UCEC	YTHDF3-AS1 →	+0.656	+3.202	.001	.009	3	1
UCEC	NOL12 →	+0.455	+2.839	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 762 associations by consensus.

SNORD126 by RDH5 expression — KIRP

Explore this box plot interactively →