RDH5

Across TCGA cell cohorts, RDH5 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RDH5-associated genes across cancer lineages are OR2M5, HRG, and TCF21. Each is linked with RDH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH5-to-partner and partner-to-RDH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by RDH5-low versus RDH5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH5→partner) and Y-score (partner→RDH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.029	+5.415	<.001	.004	3	1
BLOOD_Leukemia	HRG →	+0.267	+3.177	<.001	.004	3	1
BLOOD_Leukemia	TCF21 →	+0.011	+3.536	<.001	.001	3	1
BLOOD_Leukemia	AKR1D1 →	+0.021	+3.772	<.001	<.001	3	1
BLOOD_Leukemia	KAAG1 →	+0.070	+3.177	<.001	.004	3	1
BLOOD_Leukemia	ODF1 →	+0.065	+4.529	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

OR2M5 by RDH5 expression — LARGE_INTESTINE

Explore this box plot interactively →