RDH16

Across TCGA patient cohorts, RDH16 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,152 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible RDH16-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of stem cell population maintenance, and Positive regulation of double-strand break repair. Each is linked with RDH16 in more than 17 cancer types. Because this analysis shows association rather than direction, both RDH16-to-partner and partner-to-RDH16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by RDH16-low versus RDH16-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH16→partner) and Y-score (partner→RDH16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Positive regulation of DNA repair →	+0.050	+0.663	<.001	<.001	3	18
SCLC	Positive regulation of stem cell population maintenance →	+0.074	+0.668	<.001	<.001	3	18
SCLC	Positive regulation of double-strand break repair →	+0.105	+1.128	<.001	<.001	3	17
SCLC	Hippocampus development →	+0.054	+0.676	<.001	<.001	3	17
SCLC	Negative regulation of gene expression, epigenetic →	+0.089	+0.804	<.001	<.001	3	16
SCLC	Facultative heterochromatin formation →	+0.105	+0.864	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,152 associations by consensus.

Positive regulation of DNA repair by RDH16 expression — SCLC

Explore this box plot interactively →