RDH16

Across TCGA patient cohorts, RDH16 mutation is significantly associated with the RNA expression of many other genes, with 2,729 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH16-associated genes across cancer lineages are DDX52, ACACA, and DCP1A. Each is linked with RDH16 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH16-to-partner and partner-to-RDH16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX52 grouped by RDH16-low versus RDH16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH16→partner) and Y-score (partner→RDH16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDX52 →	+0.493	+2.343	.008	.003	3	2
UCEC	ACACA →	+0.564	+2.625	.002	.005	3	2
UCEC	DCP1A →	+0.650	+2.724	<.001	.003	3	2
UCEC	LIN7C →	+0.637	+2.708	.001	.003	3	2
UCEC	ZUP1 →	+0.585	+2.732	<.001	.003	3	2
UCEC	APOOL →	+0.554	+2.321	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,729 associations by consensus.

DDX52 by RDH16 expression — UCEC

Explore this box plot interactively →