RDH16

Across TCGA patient cohorts, RDH16 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RDH16-associated genes across cancer lineages are EGFR_pY1068, HER3, and MEK1. Each is linked with RDH16 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH16-to-partner and partner-to-RDH16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RDH16-low versus RDH16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH16→partner) and Y-score (partner→RDH16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.286	-2.700	.011	.006	3	1
UCEC	HER3 →	-0.331	-3.156	.007	.018	3	1
UCEC	MEK1 →	+0.373	+2.459	.023	.019	3	1
UCEC	MSH2 →	-0.354	-2.433	<.001	.018	3	1
UCEC	P-Cadherin →	-0.129	-2.999	.046	.035	3	1
UCEC	SF2 →	-0.140	-2.449	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by RDH16 expression — UCEC

Explore this box plot interactively →