RDH16

Across TCGA cell cohorts, RDH16 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RDH16-associated genes across cancer lineages are CFHR5, OCM2, and OR5B3. Each is linked with RDH16 in more than 1 cancer types. Because this analysis shows association rather than direction, both RDH16-to-partner and partner-to-RDH16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR5 grouped by RDH16-low versus RDH16-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RDH16→partner) and Y-score (partner→RDH16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CFHR5 →	+0.015	+3.714	<.001	.006	3	2
OVARY	OCM2 →	+1.398	+5.196	<.001	.005	3	1
SKIN	OR5B3 →	+0.038	+5.415	<.001	.004	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	SIGLEC8 →	+0.014	+3.714	.005	.006	3	1
BLOOD_Lymphoma	APOC3 →	+0.221	+3.714	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CFHR5 by RDH16 expression — BLOOD_Lymphoma

Explore this box plot interactively →